Metabolic Cages, basic model, to separate rodent's urine & feces
Features
- NEW: Tail-flick is scored automatically or manually
- NEW: fully controlled by a 4.3" touch screen
- USB memory key and software are included
- No protruding elements and unobstructed surface
- Radiant energy can be calibrated with optional Radiometer
Benefits
- Precise score, free of human variability and flexibility
Applications
The Tail Flick Unit basically consists of an I.R. source, whose radiant energy of adjusta-ble intensity is focused by an embodied parabolic mirror on the rat tail.
The animal is held by the operator on the instrument unobstructed upper panel in such a way that its tail, placed over a flush mounted window, receives the I.R. energy.
The operator starts the stimulus and the related reaction-time counter by the pedal switch or by the touch screen start icon.
When the animal feels pain and flicks its tail, a sensor detects it, stops the reaction-time counter and switches off the bulb. The reaction time of the animal is thus automatically determined to the nearest 0.1 second (unless the manual score option is activated, in which case it is the scientist to stop the counter by pressing the footswitch).
- The corticosteroid compounds prednisolone and vamorolone do not alter the nociception phenotype and exacerbate liver injury in sickle cell mice LEF Almeida, JM Damsker, S Albani, N Afsar… - Scientific Reports, 2018 (Mice)
- Effect of alpha-lipoic acid and its Nano-formulation on streptozotocin induced diabetic neuropathy in Rats P Verma – 2018
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- Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators N Tsuno, J Yao - US Patent 9,890,164, 2018
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Method Paper
- F.E. D’Amour & D.L. Smith: "A Method for Determining Loss of Pain Sensation." J. Pharmacol. Exp. Therap. 72: 74-79, 1941.