Type: Inbred mice
Origin: The C57BL/6 mouse was developed by C.C. Little in 1921, after crossing the female N.57 with the male N.52 from a commercial breeding centre in the United States (Miss Abby Lathrop). It was introduced into The Jackson Laboratory in 1948, at F22, then to Charles River Laboratories France in 1981 and UK in 2004. Breeding is in accordance with The Jackson Laboratory genetic management system.
C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss (this strain is homozygous for Cdh23ahl). They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. Macrophages from this strain are resistant to the effects of anthrax lethal toxin.
Coat color: Black
Strain code: 632
Ideal for: General multipurpose model, diet-induced obesity, transgenic/knockout model development, safety and efficacy testing, immunology
JAX™ Stock No: 000664
More information about the strain:
Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.
JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
Bred in: Germany, UK, France
Health reports: Using strain nomenclature find the strain at links below
- animals health reports bred in Charles River Germany
- animals health reports bred in Charles River UK
- animals health reports bred in Charles River France
Note: We also offer C57BL/6J mice with a SOPF health profile.
*Photos provided courtesy of Charles River