The Jackson Laboratory

C57BL/6J Mouse (JAX™)

Code 2498079-86

General multipurpose model, diet-induced obesity, transgenic/knockout model development, safety and efficacy testing, immunology.

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Imunoloģija Metabolisms Aptaukošanās, liekais svars Novecošana Toksikaloģijas Transgenēze, mērķētas mutācijas

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Nomenclature: C57BL/6J

Type: Inbred mice

Origin: The C57BL/6 mouse was developed by C.C. Little in 1921, after crossing the female N.57 with the male N.52 from a commercial breeding centre in the United States (Miss Abby Lathrop). It was introduced into The Jackson Laboratory in 1948, at F22, then to Charles River Laboratories France in 1981 and UK in 2004. Breeding is in accordance with The Jackson Laboratory genetic management system.

C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss (this strain is homozygous for Cdh23^ahl). They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. Macrophages from this strain are resistant to the effects of anthrax lethal toxin.

Coat color: Black

Strain code: 632

Ideal for: General multipurpose model, diet-induced obesity, transgenic/knockout model development, safety and efficacy testing, immunology

JAX™ Stock No: 000664

More information about the strain:

Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.

Charles River Laboratories is the official distributor of JAX mice in Europe. Click and read more.

Bred in: Germany, UK, France

Health reports: Using strain nomenclature find the strain at links below

Note: We also offer C57BL/6J mice with a SOPF health profile.

*Photos provided courtesy of Charles River

Atsisiųsti

Strategies to minimize genetic drift and maximize experimental reproducibility in mouse research

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Importing specialised JAX strains through Charles River Europe EN

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