LVG Golden Syrian Hamster, Crl:LVG(SYR)
Nomenclature: Crl:LVG(SYR)
Type: Outbred
Origin: The Golden Syrian Hamster is applicable for studies relating to SARS-CoV-2 due to its high levels of sequence homology with human ACE2 receptors and strong viral titers within 48 hours of inoculation. The model exhibits maximum clinical signs such as high lung viral load, cytokine activation, spleen and lymphoid atrophy, and can develop serum antibodies. Three members of a litter captured in Syria in 1930 were retained in captivity. It is the progeny of these golden hamsters that were first imported to the United States in 1938. Descended from two original colonies acquired by Lakeview in 1949 and 1951. Closed outbred colony since 1951. To Charles River in 1969.
Coat color: Medium tan
Strain codes: 049
Ideal for:SARS-CoV-2, carcinogenicity, behavioral studies, toxicity, infectious disease, general multipurpose model
How are Golden Syrian Hamsters used in SARS-CoV2 research?
The LVG Golden Syrian Hamster supports growth of SARS-CoV-2 with robust viral titers within 48 hours of inoculation. Ease of handling, natural infection, and efficient transmission make this an ideal research model for your COVID-19 studies. Applications:
- Investigation of pathogenesis and transmission of SARS-CoV-2
- Vaccine and treatment generation against SARS-CoV-2
What are some features of the LVG Golden Syrian Hamster?
- High level of sequence homology with human ACE2 receptor
- Consistent infection with SARS-CoV-2
- Maximum clinical signs such as alveolar damage, high lung viral load, cytokine activation, spleen and lymphoid atrophy, and development of serum antibodies
Bred in: US
Health reports: Using strain nomenclature find the strain at link below
*Photos provided courtesy of Charles River
- Animal Models and Vaccines for SARS-CoV Infection
- Is There an Ideal Animal Model for SARS?
- Attenuated SARS-CoV-2 Variants with Deletions at the S1/S2 Junction
- Pathogenesis and Transmission of SARS-CoV-2 Virus in Golden Syrian Hamsters
- Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility
- Rapid Isolation of Potent SARS-CoV-2 Neutralizing Antibodies and Protection in a Small Animal Model
- Syrian Hamster as an Animal Model for the Study on Infectious Diseases
- Mice, Hamsters, Ferrets, Monkeys. Which Lab Animals Can Help Defeat the New Coronavirus?
- Coronavirus: Hamsters May Show Path Toward Reducing Viral Load in Covid-19 Patients, Hong Kong Microbiology Team Finds
- Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters
- Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters
- Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters
- Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection