Hot/Cold Plate NG for screening of thermal hyperalgesia/allodynia
Features
- Entirely made of fiber glass
- Embedded wheels and drain hose
- Embedded connectors for hydraulic platforms
- Inlet and outlet connectors provided
- Ample color selection
Benefits
- Light, resistant, durable and easy to clean
- Easy to move, empty and store
- Ready to be upgraded to Atlantis Platforms
- Ready for use with our heater/circulator
- Optimal results with any Video-Tracking software
Application
The test that is referred to as "the water maze" was developed by Richard Morris. The maze is therefore referred to as "the Morris watermaze".
The Morris water maze is a test of spatial learning for rondents that relies on distal cues to navigate from start locations around the perimeter of an open swimming arena, to locate a submerged escape platform. Spatial learning is assessed across repeated trials and reference memory is determined by preference for the platform area when the platform is absent.
Reversal and shift trial enhance the detection of spatial impariments.
Search-to-platform area determines the degree of reliance on spatial versus non-spatial strategies. Cued trials determine whether performance factors tha are unrelated to place learning are present.
- Effect of methionine-induced hyperhomocysteinemia on neurodegeneration in experimental conditions B Tóthová, M Kovalská, D Kalenská, A Beňová, 2017
- Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's … V Pilipenko, K Narbute, U Beitnere, J Rumaks… - European Journal of Pharmacology, 2017
- D. Ryan et alia: "Spatial Learning Impairments in PLB1Triple Knock-In Alzheimer Mice are Task-Specific and Age-Dependent" Cellular and molecular life sciences 70(14)): 2603-2619, 2013
- G.M. Rose et alia: "Water Maze Testing to Identify Compounds for Cognitive Enhancement" Current protocols in pharmacology :5-63, 2012
Method paper
- Richard Morris: "Developments of a Water-Maze Procedure for Studying Spatial lEarning in the Rat" Journal of neuroscience methods 11(1): 47-60, 1984
- I.Q. Wihshaw et alia: “The Behavior of the Laboratory Rat: A Handbook with Tests” Oxford Univ. Press: 1, 2004
- R. D’Hooge et alia: "Applications of the Morris Water Maze in the Study of Learning and Memory." Brain research reviews 36(1): 60-90, 2001
- G. Riedel et alia: "Reversible Neural Inactivation Reveals Hippocampal Participation in Several Memory Processes" Nature neuroscience 2(10): 898-905, 1999