Ugo Basile

Rodent Treadmill NG with interchangeable lane assembly for rats or mice

Code 47300UB
The new Ugo Basile Conditioned Place Preference (CPP) cage is a 2-compartment box to evaluate the abuse potential of substances and the motivational effects of drugs in mice or rats.
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funkcijos

Features

  • Interchangeable patterned floors and walls
  • Walls in either compartment can be altered, by replacing the context kit
  • High contrast with light or dark animals
  • Specific models and floors for rats or mice

Benefits

  • The two compartments differ by tactile stimulation
  • The two compartments differ by visual stimulation
  • Optimized for Video-Tracking
  • Designed for multiple-cage systems

Applications

The CPP paradigm provides information on the rewarding or aversive effects of visible and tactile contextual cues associated with drugs. 

This technique has acquired great popularity in research studies involving addiction, being much easier, if compared to drug self-administration procedures. 

First, the animal is conditioned to identify one of the two compartments with the drug experience. Then the time spent in each compartments is measured; preference or
aversion to the drug-paired compartment, hence rewarding/aversive properties of drugs, can be easily deducted.

The CPP test only requires the animal to carry out a simple operation (i.e. move from one compartment to the other) to approach or avoid the drug-paired compartment; the animal is expected to spend more time in the drug-paired compartment, if the drug experience produced a positive effect.

Detailed information on UGO BASILE website.

Leidiniai

Special thanks to Prof. Paola Fadda (Department of Pharmacology, University of Cagliari, Italy) for the initial design of the boxes: her valuable comments and suggestions allowed us to keep the focus on the user needs and opinions.