ob/ob mice (JAX™); B6.Cg-Lepob/J
Nomenclature: B6.Cg-Lepob/J
Type: Inbred mice
Origin: The obese mutation, ob, arose spontaneously in strain V/Le at The Jackson Laboratory, Bar Harbor, Maine in 1949, and has been backcrossed to C57BL/6J for more than 45 generations.
Also known as B6 ob, these animals are homozygous for the obese spontaneous mutation, Lepob (often referred to as ob or ob/ob), show obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin. Ob/ob mice are also hypometabolic, hypothermic, and often subfertile. Hormone production from both pituitary and adrenal glands is increased, and wound healing is impaired. Ob/ob mice are commonly used to model phases 1 and 2 of diabetes type II, as well as obesity. The obesity is characterized by a growth in the number and size of adipocytes. Although hyperphagia furthers the obesity, homozygotes gain weight and deposit surplus fat even when restricted to a diet sufficient for normal weight maintenance in lean mice.
Coat color: Black
Strain code: 606
Ideal for: Phase I and II type 2 diabetes, obesity research, wound healing
JAX™ Stock No: 000632
More information about the strain:
Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.
JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
Charles River Laboratories is the official distributor of JAX mice in Europe. Click and read more.
Bred in: Italy
Health reports: Using strain nomenclature find the strain at links below
*Photos provided courtesy of Charles River