Ugo Basile
Conditioned Place Preference (CPP) Cages for rats or mice
Code 42552/3UB
The Durham Animal Holders are new rat holders for trigeminal stimulation, the newest accessory for use with the Plantar Test and Dynamic Plantar Aesthesiometer, manufactured by Ugo Basile.
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funkcijos
Features
- Correlation thresholds in submandibular (trigeminal) region and hindpaw plantar surface
- Test orofacial nociception using a standard Plantar thermal or mechanical stimulator
Benefits
- A step forward toward multifactorial measurement of pain-related sensitivity in animal research
- The new holders complete the scope of the thermal or mechanical stimulators used for assessing hind paw withdrawal
Application
The Durham Holders have distinct advantages which make them ideal as accessories to the classical Hargreaves test and they represent a step forward toward a multifactorial measurement of pain-related sensitivity in animal research.
Quantification of localized hypersensitivity is common in the clinic, but not in animal experiments.
The holders may appear similar to the classic Broome style animal holder; however, those restrainers are clunky, made of clear acrylic, and do not have stimulus apertures, so they could never be used for this stimulation.
Leidiniai
- R.J. Cady et alia: “Dual Orexin Receptor Antagonist 12 Inhibits Expression of Proteins in Neurons and Glia Implicated in Peripheral and Central Sensitization” Neuroscience 269; 79–92, 2014
- J. L. Hawkins, et alia: “Nicotine Stimulates Expression of Proteins Implicated in Peripheral and Central Sensitization” Neuroscience 290; 115–125, 2015
Method paper
- F.G. Garrett, et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigeminal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 No. 4, 336- 344, 2012
- F.G. Garrett, A.E. Overmyer, L.A. Vause, J.L. Hawkins, J.B. Hayden, and P.L. Durham “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 2010